Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art
نویسندگان
چکیده
The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types solid tumours. In particular, protons are well known sparing normal tissues and increasing overall index. Recent studies show that tissue can be further enhanced through proton delivery at 100 Gy/s above, so-called FLASH regime. This generated very significant interest assessing biological effects pulses delivered high dose rates. Laser-accelerated beams have unique temporal emission properties, which exploited to deliver Gy level doses single or multiple rates exceeding by orders magnitude those currently used approaches. An extensive investigation radiobiology laser-driven is therefore not only necessary future clinical application, but also offers opportunity accessing yet untested regimes radiobiology. paper provides an updated review recent progress achieved ultra-high rate experiments employing protons, including a brief discussion relevant methodology dosimetry
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ژورنال
عنوان ژورنال: Frontiers in Physics
سال: 2021
ISSN: ['2296-424X']
DOI: https://doi.org/10.3389/fphy.2021.624963